Lipogenesis in Nasonia vitripennis: Influence of sugar chemistry, preferential production of triacylglycerides, and comparison of fatty acid biosynthetic capacity with Drosophila melanogaster

URN to cite this document:

urn:nbn:de:bvb:355-epub-590332 Copy

DOI to cite this document:

10.5283/epub.59033 Copy

Ruther, Joachim ; Hoheneder, Julian ; Koschany, Vera

License: Creative Commons Attribution Non-commercial No Derivatives 4.0 PDF - Published Version (2MB)

Date of publication of this fulltext: 03 Sep 2024 04:30

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Details

Item type:	Article
Open Access Type:	DEAL (Elsevier)
Journal or Publication Title:	Insect Biochemistry and Molecular Biology
Publisher:	Elsevier
Volume:	173
Page Range:	p. 104179
Date:	28 August 2024
Institutions:	Biology, Preclinical Medicine > Institut für Zoologie > Chemische Ökologie (Prof. Dr. Joachim Ruther)
Identification Number:	Value Type 10.1016/j.ibmb.2024.104179 DOI
Keywords:	Biosynthesis, Fatty acid, Fructose, Galactose, Glucose, Hymenoptera, Lipogenesis, Parasitoid, Stable isotope labeling, Sucrose, Trehalose, Triacyl glyceride
Dewey Decimal Classification:	500 Science > 570 Life sciences 500 Science > 590 Zoological sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	59033

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Abstract

Sugar consumption increases the fecundity and longevity in many species of parasitic wasps (parasitoids) but whether these insects use sugars to synthesize significant amounts of fatty acids and storage fat de novo (lipogenesis) is discussed controversially. It has long been assumed that parasitic wasps lost this ability during evolution, mainly because in several species wasps with ad libitum ...

Abstract

Sugar consumption increases the fecundity and longevity in many species of parasitic wasps (parasitoids) but whether these insects use sugars to synthesize significant amounts of fatty acids and storage fat de novo (lipogenesis) is discussed controversially. It has long been assumed that parasitic wasps lost this ability during evolution, mainly because in several species wasps with ad libitum access to sugar did not increase teneral lipid levels. Recent studies demonstrated that many species are nonetheless capable of synthesizing fatty acids de novo from glucose. It is unclear, however, whether also other sugars are used for fatty acid biosynthesis and whether an increase of sugar concentration to levels occurring in natural sugar sources translates into higher fatty acid production. Furthermore, it has been suggested that fatty acid production in parasitoids is negligible compared to species increasing teneral fat reserves such as Drosophila melanogaster. Here we show by stable isotope labeling experiments that females of Nasonia vitripennis convert D-glucose, D-fructose, sucrose, and α,α-trehalose, major sugars consumed by adult parasitoids in nature, equally well to palmitic, stearic, oleic, and linoleic acid. Lipogenesis from D-galactose occurs as well albeit to a lesser extent. Sugar concentration is crucial for lipogenic activity, and almost 80% of de novo synthesized fatty acids were incorporated into storage fat (triacylglycerides). Comparison of fatty acid biosynthesis within a 48-h feeding period with D. melanogaster revealed that N. vitripennis produced approximately half as many fatty acids per body mass unit. Both species fed equal amounts of the glucose offered. We conclude that lipogenesis is far from negligible in N. vitripennis and plays an important role for the energy balance when teneral lipid reserves deplete.

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Metadata last modified: 17 Jan 2025 10:48

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