The effector program of human CD8 T cells supports tissue remodeling

URN to cite this document:: urn:nbn:de:bvb:355-epub-591648
DOI to cite this document:: 10.5283/epub.59164

Delacher, Michael

; Schmidleithner, Lisa

; Simon, Malte

; Stüve, Philipp

; Sanderink, Lieke

; Hotz-Wagenblatt, Agnes ; Wuttke, Marina

; Schambeck, Kathrin

; Ruhland, Brigitte

; Hofmann, Veronika

; Bittner, Sebastian

; Ritter, Uwe

; Pant, Asmita

; Helbich, Sara Salome ; Voss, Morten ; Lemmermann, Niels A. ; Bessiri-Schake, Lisa ; Bohn, Toszka ; Eigenberger, Andreas

; Menevse, Ayse Nur

; Gebhard, Claudia

; Strieder, Nicholas

; Abken, Hinrich

; Rehli, Michael

; Huehn, Jochen ; Beckhove, Philipp

; Hehlgans, Thomas

; Junger, Henrik

; Geissler, Edward K.

; Prantl, Lukas

; Werner, Jens M.

; Schmidl, Christian

; Brors, Benedikt ; Imbusch, Charles D. ; Feuerer, Markus

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Sep 2024 15:50

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Abstract

CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-specific assay systems revealed that human CD8 T cells not only mediated cytotoxicity but also promoted tissue remodeling. Activated CD8 T cells could produce the epidermal growth factor receptor (EGFR)-ligand ...