Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF

URN to cite this document:: urn:nbn:de:bvb:355-epub-592880
DOI to cite this document:: 10.5283/epub.59288

Hupfeld, Enrico ; Schlee, Sandra ; Wurm, Jan Philip

; Rajendran, Chitra ; Yehorova, Dariia ; Vos, Eva ; Ravindra Raju, Dinesh ; Kamerlin, Shina Caroline Lynn ; Sprangers, Remco

; Sterner, Reinhard

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Sep 2024 13:03

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Abstract

The overall significance of loop motions for enzymatic activity is generally accepted. However, it has largely remained unclear whether and how such motions can control different steps of catalysis. We have studied this problem on the example of the mobile active site β1α1-loop (loop1) of the (βα)8-barrel enzyme HisF, which is the cyclase subunit of imidazole glycerol phosphate synthase. Loop1 ...