Rethinking Thin-Layer Chromatography for Screening Technetium-99m Radiolabeled Polymer Nanoparticles

URN to cite this document:: urn:nbn:de:bvb:355-epub-592907
DOI to cite this document:: 10.5283/epub.59290

Schorr, Kathrin ; Chen, Xinyu ; Sasaki, Takanori ; Arias-Loza, Anahi Paula ; Lang, Johannes ; Higuchi, Takahiro ; Goepferich, Achim

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Sep 2024 14:27

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Abstract

Thin-layer chromatography (TLC) is commonly employed to screen technetium-99m labeled polymer nanoparticle batches for unreduced pertechnetate and radio-colloidal impurities. Although this method is widely accepted, our findings applying radiolabeled PLGA/PLA–PEG nanoparticles underscore its lack of transferability between different settings and its limitations as a standalone quality control ...