Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays

URN to cite this document:: urn:nbn:de:bvb:355-epub-593031
DOI to cite this document:: 10.5283/epub.59303

Ertl, Fabian J. ; Kopanchuk, Sergei

; Dijon, Nicola C. ; Veikšina, Santa ; Tahk, Maris-Johanna

; Laasfeld, Tõnis ; Schettler, Franziska ; Gattor, Albert O. ; Hübner, Harald ; Archipowa, Nataliya

; Köckenberger, Johannes ; Heinrich, Markus R. ; Gmeiner, Peter

; Kutta, Roger Jan

; Holliday, Nicholas D.

; Rinken, Ago

; Keller, Max

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 01 Oct 2024 08:45

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Abstract

The determination of ligand–receptor binding affinities plays a key role in the development process of pharmaceuticals. While the classical radiochemical binding assay uses radioligands, fluorescence-based binding assays require fluorescent probes. Usually, radio- and fluorescence-labeled ligands are dissimilar in terms of structure and bioactivity, and can be used in either radiochemical or ...