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Indole in DNA: Comparison of nucleosidic with a non-nucleosidic DNA base substitution

Barbaric, Janez, Wanninger-Weiss, Claudia and Wagenknecht, Hans-Achim (2009) Indole in DNA: Comparison of nucleosidic with a non-nucleosidic DNA base substitution. European Journal of Organic Chemistry 2009, pp. 364-370.

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The synthetic incorporation of indole as an artificial DNA base into oligonucleotides by two different structural approaches is described. For both types of modification, the indole moiety is attached through the C-3 position to the oligonucleotides. As a mimic of natural nucleosides, the indole nucleoside of β-2'-deoxyribofuranoside (In) was synthesized. The corresponding In-modified duplexes ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Alumni or Retired Professors > Arbeitskreis Prof. Dr. Hans-Achim Wagenknecht
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Keywords:Nitrogen heterocycles; DNA; Oligonucleotides; Nucleosides
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:5934
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