Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (3MB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-595436
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.59543
Dokumentenart: | Artikel | ||||
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Open Access Art: | DEAL (Elsevier Gold) | ||||
Titel eines Journals oder einer Zeitschrift: | eBioMedicine | ||||
Verlag: | Elsevier | ||||
Band: | 110 | ||||
Seitenbereich: | S. 105438 | ||||
Datum: | 9 November 2024 | ||||
Institutionen: | Medizin > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medizin > Abteilung für Krankenhaushygiene und Infektiologie | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | SARS-CoV-2, COVID-19 breakthrough infection, Neutralization, Immune imprinting, Magnitude-breadth, Antigenic map, Machine learning | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Zum Teil | ||||
Dokumenten-ID: | 59543 |
Zusammenfassung
Background The impact of the infecting SARS-CoV-2 variant of concern (VOC) and the vaccination status was determined on the magnitude, breadth, and durability of the neutralizing antibody (nAb) profile in a longitudinal multicentre cohort study. Methods 173 vaccinated and 56 non-vaccinated individuals were enrolled after SARS-CoV-2 Alpha, Delta, or Omicron infection and visited four times ...
Zusammenfassung
Background
The impact of the infecting SARS-CoV-2 variant of concern (VOC) and the vaccination status was determined on the magnitude, breadth, and durability of the neutralizing antibody (nAb) profile in a longitudinal multicentre cohort study.
Methods
173 vaccinated and 56 non-vaccinated individuals were enrolled after SARS-CoV-2 Alpha, Delta, or Omicron infection and visited four times within 6 months and nAbs were measured for D614G, Alpha, Delta, BA.1, BA.2, BA.5, BQ.1.1, XBB.1.5 and JN.1.
Findings
Magnitude-breadth-analysis showed enhanced neutralization capacity in vaccinated individuals against multiple VOCs. Longitudinal analysis revealed sustained neutralization magnitude-breadth after antigenically distant Delta or Omicron breakthrough infection (BTI), with triple vaccinated individuals showing significantly elevated titres and improved breadth. Antigenic mapping and antibody landscaping revealed initial boosting of vaccine-induced WT-specific responses after BTI, a shift in neutralization towards infecting VOCs at peak responses and an immune imprinted bias towards dominating WT immunity in the long-term. Despite that bias, machine-learning models confirmed a sustained shift of the immune-profiles following BTI.
Interpretation
In summary, our longitudinal analysis revealed delayed and short lived nAb shifts towards the infecting VOC, but an immune imprinted bias towards long-term vaccine induced immunity after BTI.
Funding
This work was funded by the Bavarian State Ministry of Science and the Arts for the CoVaKo study and the ForCovid project. The funders had no influence on the study design, data analysis or data interpretation.
Metadaten zuletzt geändert: 12 Nov 2024 05:21