Divergent effects of itaconate isomers on Coxiella burnetii growth in macrophages and in axenic culture

URN to cite this document:: urn:nbn:de:bvb:355-epub-596672
DOI to cite this document:: 10.5283/epub.59667

Siddique, Md Nur A Alam ; Kellermeier, Fabian ; Ölke, Martha ; Zhao, Mingming ; Büssow, Konrad ; Oefner, Peter J. ; Lührmann, Anja ; Dettmer, Katja ; Lang, Roland

License: Creative Commons Attribution 4.0
PDF - Published Version
(2MB)

Date of publication of this fulltext: 21 Nov 2024 14:47

Alternative links to fulltext:DOI Pubmed Pubmed Central Publisher

Details

Preview

Export bibliographical data

Abstract

Aconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects. ACOD1-itaconate is essential for macrophage-mediated control of the intracellular pathogen Coxiella (C.) burnetii, which causes Q fever. Two isomers of itaconate, mesaconate and citraconate, have overlapping yet distinct activity on macrophage ...