Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension

URN to cite this document:: urn:nbn:de:bvb:355-epub-596701
DOI to cite this document:: 10.5283/epub.59670

Wimmer, Moritz I. ; Bartolomaeus, Hendrik

; Anandakumar, Harithaa ; Chen, Chia-Yu ; Vecera, Valentin ; Kedziora, Sarah ; Kamboj, Sakshi ; Schumacher, Fabian ; Pals, Sidney ; Rauch, Ariana ; Meisel, Jutta ; Potapenko, Olena ; Yarritu, Alex ; Bartolomaeus, Theda U. P. ; Samaan, Mariam ; Thiele, Arne ; Stürzbecher, Lucas ; Geisberger, Sabrina Y. ; Kleuser, Burkhard ; Oefner, Peter J. ; Haase, Nadine

; Löber, Ulrike ; Gronwald, Wolfram

; Forslund-Startceva, Sofia K. ; Müller, Dominik N. ; Wilck, Nicola

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Nov 2024 11:44

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Abstract

Aims: Metformin has been attributed to cardiovascular protection even in the absence of diabetes. Recent observations suggest that metformin influences the gut microbiome. We aimed to investigate the influence of metformin on the gut microbiota and hypertensive target organ damage in hypertensive rats. Methods: Male double transgenic rats overexpressing the human renin and angiotensinogen ...