Genetic-by-age interaction analyses on complex traits in UK Biobank and their potential to identify effects on longitudinal trait change

URN to cite this document:: urn:nbn:de:bvb:355-epub-597195
DOI to cite this document:: 10.5283/epub.59719

Winkler, Thomas W.

; Wiegrebe, Simon ; Herold, Janina M. ; Stark, Klaus J. ; Küchenhoff, Helmut ; Heid, Iris M.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Dec 2024 10:08

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Abstract

Background: Genome-wide association studies (GWAS) have identified thousands of loci for disease-related human traits in cross-sectional data. However, the impact of age on genetic effects is underacknowledged. Also, identifying genetic effects on longitudinal trait change has been hampered by small sample sizes for longitudinal data. Such effects on deteriorating trait levels over time or ...