A Comprehensive Functional Investigation of the Human Translocator Protein 18 kDa (TSPO) in a Novel Human Neuronal Cell Knockout Model

URN to cite this document:: urn:nbn:de:bvb:355-epub-598238
DOI to cite this document:: 10.5283/epub.59823

Bader, Stefanie

; Jahner, Tatjana ; Dörfelt, Anett ; Melchner, Doris ; Cardon, Iseline

; Siegmund, Heiko Ingo ; Brochhausen, Christoph

; Rupprecht, Rainer

; Milenkovic, Vladimir M.

; Wetzel, Christian H.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Dec 2024 13:13

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Abstract

The translocator protein 18 kDa (TSPO) is a multifunctional outer mitochondrial membrane protein associated with various aspects of mitochondrial physiology and multiple roles in health and disease. Here, we aimed to analyse the role of TSPO in the regulation of mitochondrial and cellular functions in a human neuronal cell model. We used the CRISPR/Cas9 technology and generated TSPO knockout (KO) ...