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Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

Marschallinger, Julia ; Schäffner, Iris ; Klein, Barbara ; Gelfert, Renate ; Rivera, Francisco J. ; Illes, Sebastian ; Grassner, Lukas ; Janssen, Maximilian ; Rotheneichner, Peter ; Schmuckermair, Claudia ; Coras, Roland ; Boccazzi, Marta ; Chishty, Mansoor ; Lagler, Florian B. ; Renic, Marija ; Bauer, Hans-Christian ; Singewald, Nicolas ; Blümcke, Ingmar ; Bogdahn, Ulrich ; Couillard-Despres, Sebastien ; Lie, D. Chichung ; Abbracchio, Maria P. ; Aigner, Ludwig



Zusammenfassung

As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-related cognitive declines, such as neuroinflammation, low levels of neurogenesis, disrupted blood-brain barrier and altered neuronal activity, might lead to structural and functional ...

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