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CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells

Kara, Ervin E. ; McKenzie, Duncan R. ; Bastow, Cameron R. ; Gregor, Carly E. ; Fenix, Kevin A. ; Ogunniyi, Abiodun D. ; Paton, James C. ; Mack, Matthias ; Pombal, Diana R. ; Seillet, Cyrill ; Dubois, Bénédicte ; Liston, Adrian ; MacDonald, Kelli P. A. ; Belz, Gabrielle T. ; Smyth, Mark J. ; Hill, Geoffrey R. ; Comerford, Iain ; McColl, Shaun R.



Zusammenfassung

IL-17-producing helper T (Th17) cells are critical for host defense against extracellular pathogens but also drive numerous autoimmune diseases. Th17 cells that differ in their inflammatory potential have been described including IL-10-producing Th17 cells that are weak inducers of inflammation and highly inflammatory, IL-23-driven, GM-CSF/IFN gamma-producing Th17 cells. However, their distinct ...

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