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Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists

Igel, Patrick ; Geyer, Roland ; Straßer, Andrea ; Dove, Stefan ; Seifert, Roland ; Buschauer, Armin


Recently, we identified high-affinity human histamine H3 (hH3R) and H4 receptor (hH4R) ligands among a series of NG-acylated imidazolylpropylguanidines, which were originally designed as histamine H2 receptor (H2R) agonists. Aiming at selectivity for hH4R, the acylguanidine group was replaced with related moieties. Within a series of cyanoguanidines, ...


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