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Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

Bruttger, Julia ; Karram, Khalad ; Wörtge, Simone ; Regen, Tommy ; Marini, Federico ; Hoppmann, Nicola ; Klein, Matthias ; Blank, Thomas ; Yona, Simon ; Wolf, Yochai ; Mack, Matthias ; Pinteaux, Emmanuel ; Müller, Werner ; Zipp, Frauke ; Binder, Harald ; Bopp, Tobias ; Prinz, Marco ; Jung, Steffen ; Waisman, Ari



Zusammenfassung

During early embryogenesis, microglia arise from yolk sac progenitors that populate the developing central nervous system (CNS), but how the tissue-resident macrophages are maintained throughout the organism's lifespan still remains unclear. Here, we describe a system that allows specific, conditional ablation of microglia in adult mice. We found that the microglial compartment was reconstituted ...

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