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Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia

Rietkötter, Eva ; Bleckmann, Annalen ; Bayerlová, Michaela ; Menck, Kerstin ; Chuang, Han-Ning ; Wenske, Britta ; Schwartz, Hila ; Erez, Neta ; Binder, Claudia ; Hanisch, Uwe-Karsten ; Pukrop, Tobias



Zusammenfassung

The mononuclear phagocytic system is categorized in three major groups: monocyte-derived cells (MCs), dendritic cells and resident macrophages. During breast cancer progression the colony stimulating factor 1 (CSF-1) can reprogram MCs into tumor-promoting macrophages in the primary tumor. However, the effect of CSF-1 during colonization of the brain parenchyma is largely unknown. Thus, we ...

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