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DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance

Conde, Patricia ; Rodriguez, Mercedes ; van der Touw, William ; Jimenez, Ana ; Burns, Matthew ; Miller, Jennifer ; Brahmachary, Manisha ; Chen, Hui-ming ; Boros, Peter ; Rausell-Palamos, Francisco ; Yun, Tae Jin ; Riquelme, Paloma ; Rastrojo, Alberto ; Aguado, Begoña ; Stein-Streilein, Joan ; Tanaka, Masato ; Zhou, Lan ; Zhang, Junfeng ; Lowary, Todd L. ; Ginhoux, Florent ; Park, Chae Gyu ; Cheong, Cheolho ; Brody, Joshua ; Turley, Shannon J. ; Lira, Sergio A. ; Bronte, Vincenzo ; Gordon, Siamon ; Heeger, Peter S. ; Merad, Miriam ; Hutchinson, James ; Chen, Shu-Hsia ; Ochando, Jordi



Zusammenfassung

Tissue effector cells of the monocyte lineage can differentiate into different cell types with specific cell function depending on their environment. The phenotype, developmental requirements, and functional mechanisms of immune protective macrophages that mediate the induction of transplantation tolerance remain elusive. Here, we demonstrate that costimulatory blockade favored accumulation of ...

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