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Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms

Baurecht, Hansjörg ; Hotze, Melanie ; Brand, Stephan ; Büning, Carsten ; Cormican, Paul ; Corvin, Aiden ; Ellinghaus, David ; Ellinghaus, Eva ; Esparza-Gordillo, Jorge ; Fölster-Holst, Regina ; Franke, Andre ; Gieger, Christian ; Hubner, Norbert ; Illig, Thomas ; Irvine, Alan D. ; Kabesch, Michael ; Lee, Young A.E. ; Lieb, Wolfgang ; Marenholz, Ingo ; McLean, W.H. Irwin ; Morris, Derek W. ; Mrowietz, Ulrich ; Nair, Rajan ; Nöthen, Markus M. ; Novak, Natalija ; O’Regan, Grainne M. ; Schreiber, Stefan ; Smith, Catherine ; Strauch, Konstantin ; Stuart, Philip E. ; Trembath, Richard ; Tsoi, Lam C. ; Weichenthal, Michael ; Barker, Jonathan ; Elder, James T. ; Weidinger, Stephan ; Cordell, Heather J. ; Brown, Sara J.



Zusammenfassung

Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive clinical phenotypes and opposing immune mechanisms. Despite their prevalence, atopic dermatitis and psoriasis very rarely co-occur within one individual. By utilizing ...

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