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Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

Tsaprouni, Loukia G ; Yang, Tsun-Po ; Bell, Jordana ; Dick, Katherine J ; Kanoni, Stavroula ; Nisbet, James ; Viñuela, Ana ; Grundberg, Elin ; Nelson, Christopher P ; Meduri, Eshwar ; Buil, Alfonso ; Cambien, Francois ; Hengstenberg, Christian ; Erdmann, Jeanette ; Schunkert, Heribert ; Goodall, Alison H ; Ouwehand, Willem H ; Dermitzakis, Emmanouil ; Spector, Tim D ; Samani, Nilesh J ; Deloukas, Panos



Zusammenfassung

Smoking is a major risk factor in many diseases. Genome wide association studies have linked genes for nicotine dependence and smoking behavior to increased risk of cardiovascular, pulmonary, and malignant diseases. We conducted an epigenome wide association study in peripheral-blood DNA in 464 individuals (22 current smokers and 263 ex-smokers), using the Human Methylation 450K array. Upon ...

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