Krautbauer, Sabrina ; Eisinger, Kristina ; Hader, Yvonne ; Buechler, Christa
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
|---|
| Titel eines Journals oder einer Zeitschrift: | Cytokine |
|---|
| Verlag: | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
|---|
| Ort der Veröffentlichung: | LONDON |
|---|
| Band: | 69 |
|---|
| Nummer des Zeitschriftenheftes oder des Kapitels: | 2 |
|---|
| Seitenbereich: | S. 263-271 |
|---|
| Datum: | 2014 |
|---|
| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I |
|---|
| Identifikationsnummer: | | Wert | Typ |
|---|
| 10.1016/j.cyto.2014.06.016 | DOI |
|
|---|
| Stichwörter / Keywords: | GLYCATION END-PRODUCTS; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; POSSIBLE RELEVANCE; LIVER-DISEASE; HIGH GLUCOSE; EXPRESSION; INFLAMMATION; GENE; METABOLISM; Brown fat; Free fatty acid; Lipopolysaccharide; Obesity |
|---|
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
|---|
| Status: | Veröffentlicht |
|---|
| Begutachtet: | Ja, diese Version wurde begutachtet |
|---|
| An der Universität Regensburg entstanden: | Ja |
|---|
| Dokumenten-ID: | 61129 |
|---|
Web of Science
Zusammenfassung
Galectin-3 regulates immune cell function and clearance of advanced glycation end products. Galectin-3 is increased in serum of obese humans and mice and most studies suggest that this protein protects from inflammation in metabolic diseases. Current data show that galectin-3 is markedly elevated in the liver, subcutaneous and intra-abdominal fat depots of mice fed a high fat diet and ob/ob mice. ...
Zusammenfassung
Galectin-3 regulates immune cell function and clearance of advanced glycation end products. Galectin-3 is increased in serum of obese humans and mice and most studies suggest that this protein protects from inflammation in metabolic diseases. Current data show that galectin-3 is markedly elevated in the liver, subcutaneous and intra-abdominal fat depots of mice fed a high fat diet and ob/ob mice. Galectin-3 is also increased in brown adipose tissues of these animals and immunohistochemistry confirms higher levels in adipocytes. Raised galectin-3 in obese white adipocytes has been described in the literature and regulation of adipocyte galectin-3 by metabolites with a role in obesity has been analyzed. Galectin-3 is expressed in 3T3-L1 fibroblasts and human preadipocytes and is modestly induced in mature adipocytes. In 3T3-L1 adipocytes galectin-3 is localized in the cytoplasm and is also detected in cell supernatants. Glucose does not alter soluble galectin-3. Lipopolysaccharide has no effect while TNF reduces and IL-6 raises this lectin in cell supernatants. Palmitate and oleate modestly elevate soluble galectin-3. Differentiation of 3T3-L1 cells in the presence of 100 mu M and 200 mu M linoleate induces soluble galectin-3 and cellular levels are upregulated by the higher concentration. Current data suggest that free fatty acids and IL-6 increase galectin-3 in adipocytes and thereby may contribute to higher levels in obesity. (C) 2014 Elsevier Ltd. All rights reserved.
Altmetric