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Enzyme-induced modulation of the emission of upconverting nanoparticles: Towards a new sensing scheme for glucose

del Barrio, Melisa ; de Marcos, Susana ; Cebolla, Vicente ; Heiland, Josef ; Wilhelm, Stefan ; Hirsch, Thomas ; Galbán, Javier



Zusammenfassung

A new approach for the design of a fluorometric biosensor for continuous monitoring of glucose levels in biological samples based on near-infrared (NIR) excitation is described. The sensor combines the fluorescence of the enzyme glucose oxidase (GOx) chemically modified with a fluorescein derivative (FS) and the luminescent properties of upconverting luminescent nanoparticles (UCLNPs). Both, the ...

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