Evolutionary Origin and Methylation Status of Human Intronic CpG Islands that Are Not Present in Mouse

Rademacher, Katrin ; Schröder, Christopher ; Kanber, Deniz ; Klein-Hitpass, Ludger ; Wallner, Stefan ; Zeschnigk, Michael ; Horsthemke, Bernhard

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Zusammenfassung

Imprinting of the human RB1 gene is due to the presence of a differentially methylated CpG island (CGI) in intron 2, which is part of a retrocopy derived from the PPP1R26 gene on chromosome 9. The murine Rb1 gene does not have this retrocopy and is not imprinted. We have investigated whether the RB1/Rb1 locus is unique with respect to these differences. For this, we have compared the CGIs from ...