Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine

Huang, Guozheng

; Kling, Beata ; Darras, Fouad H. ; Heilmann, Jörg ; Decker, Michael

Alternative Links zum Volltext:DOI Verlag

Bibliographische Daten exportieren

Zusammenfassung

Two sets of carbamates based on the natural alkaloid evodiamine were designed, synthesized and evaluated as potential butyrylcholinesterase inhibitors. Although a set of carbamates of 3-hydroxyevodiamine (10a-f) is inactive both at AChE and BChE, carbamates of 5-deoxo-3-hydroxyevodiamine (11a-f) exhibit much better potency with selectivity toward BChE. The heptyl carbamate of ...