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Diastrophic Dysplasia Sulfate Transporter (SLC26A2) Is Expressed in the Adrenal Cortex and Regulates Aldosterone Secretion

Spyroglou, Ariadni ; Bozoglu, Tarik ; Rawal, Rajesh ; De Leonardis, Fabio ; Sterner, Christina ; Boulkroun, Sheerazed ; Benecke, Arndt G. ; Monti, Luca ; Zennaro, Maria-Christina ; Petersen, Ann-Kristin ; Döring, Angela ; Rossi, Antonio ; Bidlingmaier, Martin ; Warth, Richard ; Gieger, Christian ; Reincke, Martin ; Beuschlein, Felix



Zusammenfassung

Elucidation of the molecular mechanisms leading to autonomous aldosterone secretion is a prerequisite to define potential targets and biomarkers in the context of primary aldosteronism. After a genome-wide association study with subjects from the population-based Cooperative Health Research in the Region of Augsburg F4 survey, we observed a highly significant association (P=6.78x10(-11)) between ...

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