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Dual Phosphorylation of Cdk1 Coordinates Cell Proliferation with Key Developmental Processes in Drosophila

Ayeni, Joseph O ; Varadarajan, Ramya ; Mukherjee, Oindrila ; Stuart, David T ; Sprenger, Frank ; Srayko, Martin ; Campbell, Shelagh D



Zusammenfassung

Eukaryotic organisms use conserved checkpoint mechanisms that regulate Cdk1 by inhibitory phosphorylation to prevent mitosis from interfering with DNA replication or repair. In metazoans, this checkpoint mechanism is also used for coordinating mitosis with dynamic developmental processes. Inhibitory phosphorylation of Cdk1 is catalyzed by Wee1 kinases that phosphorylate tyrosine 15 (Y15) and ...

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