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Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease

Dichgans, Martin ; Malik, Rainer ; König, Inke R. ; Rosand, Jonathan ; Clarke, Robert ; Gretarsdottir, Solveig ; Thorleifsson, Gudmar ; Mitchell, Braxton D. ; Assimes, Themistocles L. ; Levi, Christopher ; O´Donnell, Christopher J. ; Fornage, Myriam ; Thorsteinsdottir, Unnur ; Psaty, Bruce M. ; Hengstenberg, Christian ; Seshadri, Sudha ; Erdmann, Jeanette ; Bis, Joshua C. ; Peters, Annette ; Boncoraglio, Giorgio B. ; März, Winfried ; Meschia, James F. ; Kathiresan, Sekar ; Ikram, M. Arfan ; McPherson, Ruth ; Stefansson, Kari ; Sudlow, Cathie ; Reilly, Muredach P. ; Thompson, John R. ; Sharma, Pankaj ; Hopewell, Jemma C. ; Chambers, John C. ; Watkins, Hugh ; Rothwell, Peter M. ; Roberts, Robert ; Markus, Hugh S. ; Samani, Nilesh J. ; Farrall, Martin ; Schunkert, Heribert ; Gschwendtner, Andreas ; Bevan, Steve ; Chen, Yu-Ching ; DeStefano, Anita L. ; Parati, Eugenio A. ; Quertermous, Tom ; Ziegler, Andreas ; Boerwinkle, Eric ; Holm, Hilma ; Fischer, Marcus ; Kessler, Thorsten ; Willenborg, Christina ; Laaksonen, Reijo ; Voight, Benjamin F. ; Stewart, Alexandre F.R. ; Rader, Daniel J. ; Hall, Alistair S. ; Kooner, Jaspal S.



Zusammenfassung

Background and Purpose Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. Methods Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis ...

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