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Impact of LIF (leukemia inhibitory factor) expression in malignant melanoma

Kuphal, Silke ; Wallner, Susanne ; Bosserhoff, Anja K.



Zusammenfassung

Leukemia inhibitory factor (LIF) signaling regulates cellular processes to maintain the self-renewal and pluripotency of embryonic stem (ES) cells. Independent of these capabilities. LIF was also identified to be responsible for cancer development and progression. However, its detailed cellular function in cancer remains unclear thus far. We found LIF to be expressed in melanoma cell lines of ...

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