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A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis

Esparza-Gordillo, Jorge ; Schaarschmidt, Heidi ; Liang, Liming ; Cookson, William ; Bauerfeind, Anja ; Lee-Kirsch, Min-Ae ; Nemat, Katja ; Henderson, John ; Paternoster, Lavinia ; Harper, John I. ; Mangold, Elisabeth ; Nothen, Markus M. ; Rüschendorf, Franz ; Kerscher, Tamara ; Marenholz, Ingo ; Matanovic, Anja ; Lau, Susanne ; Keil, Thomas ; Bauer, Carl-Peter ; Kurek, Michael ; Ciechanowicz, Andrzej ; Macek, Milan ; Franke, Andre ; Kabesch, Michael ; Hubner, Norbert ; Abecasis, Gonçalo ; Weidinger, Stephan ; Moffatt, Miriam ; Lee, Young-Ae



Zusammenfassung

Background: Atopic dermatitis (AD) is a common inflammatory skin disease. Previous studies have revealed shared genetic determinants among different inflammatory disorders, suggesting that markers associated with immune-related traits might also play a role in AD. Objective: We sought to identify novel genetic risk factors for AD. Methods: We examined the results of all genome-wide association ...

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