Immobilised Zinc (II) Cyclen complexes as catalytic reagents for phosphodiester hydrolysis

Zusammenfassung

Many hydrolases found in nature have Zn(II) ions at their active site. Artificial hydrolases as alternatives for non-enzymatic hydrolysis were prepared by attaching Zn(II) cyclen complexes with an alcohol pendant to a polymeric support. These modified polymers showed a 10(4)-fold enhanced intrinsic reactivity for the hydrolysis of activated phosphodiesters over the non-catalysed reaction in solution. (c) 2005 Elsevier B.V. All rights reserved.