; Edwards, Todd L. ; Lange, Leslie A. ; Ng, Maggie C. Y. ; Adeyemo, Adebowale A.
; Allison, Matthew A.
; Bielak, Lawrence F. ; Chen, Guanjie ; Graff, Mariaelisa ; Irvin, Marguerite R. ; Rhie, Suhn K. ; Li, Guo ; Liu, Yongmei
; Liu, Youfang
; Lu, Yingchang ; Nalls, Michael A. ; Sun, Yan V. ; Wojczynski, Mary K. ; Yanek, Lisa R. ; Aldrich, Melinda C. ; Ademola, Adeyinka ; Amos, Christopher I. ; Bandera, Elisa V.
; Bock, Cathryn H. ; Britton, Angela ; Broeckel, Ulrich ; Cai, Quiyin ; Caporaso, Neil E. ; Carlson, Chris S. ; Carpten, John ; Casey, Graham ; Chen, Wei-Min ; Chen, Fang ; Chen, Yii-Der I. ; Chiang, Charleston W. K.
; Coetzee, Gerhard A. ; Demerath, Ellen ; Deming-Halverson, Sandra L. ; Driver, Ryan W. ; Dubbert, Patricia ; Feitosa, Mary F.
; Feng, Ye ; Freedman, Barry I. ; Gillanders, Elizabeth M. ; Gottesman, Omri ; Guo, Xiuqing ; Haritunians, Talin ; Harris, Tamara ; Harris, Curtis C. ; Hennis, Anselm J. M. ; Hernandez, Dena G. ; McNeill, Lorna H. ; Howard, Timothy D. ; Howard, Barbara V. ; Howard, Virginia J. ; Johnson, Karen C. ; Kang, Sun J. ; Keating, Brendan J. ; Kolb, Suzanne ; Kuller, Lewis H. ; Kutlar, Abdullah ; Langefeld, Carl D. ; Lettre, Guillaume ; Lohman, Kurt ; Lotay, Vaneet ; Lyon, Helen ; Manson, JoAnn E. ; Maixner, William ; Meng, Yan A. ; Monroe, Kristine R. ; Morhason-Bello, Imran ; Murphy, Adam B. ; Mychaleckyj, Josyf C. ; Nadukuru, Rajiv ; Nathanson, Katherine L.
; Nayak, Uma ; N'Diaye, Amidou ; Nemesure, Barbara ; Wu, Suh-Yuh ; Leske, M. Cristina ; Neslund-Dudas, Christine ; Neuhouser, Marian ; Nyante, Sarah ; Ochs-Balcom, Heather ; Ogunniyi, Adesola ; Ogundiran, Temidayo O. ; Ojengbede, Oladosu ; Olopade, Olufunmilayo I. ; Palmer, Julie R.
; Ruiz-Narvaez, Edward A.
; Palmer, Nicholette D.
; Press, Michael F. ; Rampersaud, Evandine ; Rasmussen-Torvik, Laura J. ; Rodriguez-Gil, Jorge L. ; Salako, Babatunde ; Schadt, Eric E. ; Schwartz, Ann G. ; Shriner, Daniel A.
; Siscovick, David ; Smith, Shad B. ; Wassertheil-Smoller, Sylvia ; Speliotes, Elizabeth K. ; Spitz, Margaret R. ; Sucheston, Lara ; Taylor, Herman ; Tayo, Bamidele O. ; Tucker, Margaret A. ; Van Den Berg, David J.
; Edwards, Digna R. Velez ; Wang, Zhaoming
; Wiencke, John K. ; Winkler, Thomas W. ; Witte, John S. ; Wrensch, Margaret ; Wu, Xifeng ; Yang, James J. ; Levin, Albert M. ; Young, Taylor R. ; Zakai, Neil A. ; Cushman, Mary
; Zanetti, Krista A. ; Zhao, Jing Hua ; Zhao, Wei ; Zheng, Yonglan
; Zhou, Jie ; Ziegler, Regina G. ; Zmuda, Joseph M. ; Fernandes, Jyotika K. ; Gilkeson, Gary S. ; Kamen, Diane L. ; Hunt, Kelly J. ; Spruill, Ida J. ; Ambrosone, Christine B. ; Ambs, Stefan
; Arnett, Donna K. ; Atwood, Larry ; Becker, Diane M. ; Berndt, Sonja I. ; Bernstein, Leslie ; Blot, William J. ; Borecki, Ingrid B. ; Bottinger, Erwin P. ; Bowden, Donald W. ; Burke, Gregory ; Chanock, Stephen J. ; Cooper, Richard S. ; Ding, Jingzhong ; Duggan, David ; Evans, Michele K.
; Fox, Caroline ; Garvey, W. Timothy ; Bradfield, Jonathan P. ; Hakonarson, Hakon ; Grant, Struan F. A.
; Hsing, Ann ; Chu, Lisa ; Hu, Jennifer J. ; Huo, Dezheng ; Ingles, Sue A. ; John, Esther M. ; Jordan, Joanne M. ; Kabagambe, Edmond K. ; Kardia, Sharon L. R. ; Kittles, Rick A. ; Goodman, Phyllis J. ; Klein, Eric A. ; Kolonel, Laurence N. ; Le Marchand, Loic ; Liu, Simin
; McKnight, Barbara ; Millikan, Robert C. ; Mosley, Thomas H. ; Padhukasahasram, Badri ; Williams, L. Keoki ; Patel, Sanjay R.
; Peters, Ulrike ; Pettaway, Curtis A. ; Peyser, Patricia A. ; Psaty, Bruce M. ; Redline, Susan ; Rotimi, Charles N. ; Rybicki, Benjamin A. ; Sale, Michèle M. ; Schreiner, Pamela J. ; Signorello, Lisa B. ; Singleton, Andrew B. ; Stanford, Janet L. ; Strom, Sara S. ; Thun, Michael J. ; Vitolins, Mara ; Zheng, Wei
; Moore, Jason H.
; Williams, Scott M. ; Ketkar, Shamika ; Zhu, Xiaofeng ; Zonderman, Alan B.
; Kooperberg, Charles ; Papanicolaou, George J. ; Henderson, Brian E. ; Reiner, Alex P. ; Hirschhorn, Joel N. ; Loos, Ruth J. F.
; North, Kari E. ; Haiman, Christopher A. | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Nature Genetics | ||||
| Publisher: | NATURE PUBLISHING GROUP | ||||
| Place of Publication: | NEW YORK | ||||
| Volume: | 45 | ||||
| Number of Issue or Book Chapter: | 6 | ||||
| Page Range: | pp. 690-696 | ||||
| Date: | 2013 | ||||
| Institutions: | Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
| Identification Number: |
| ||||
| Keywords: | GENOME-WIDE ASSOCIATION; MULTILOCUS GENOTYPE DATA; COMMON VARIANTS; POSITIVE SELECTION; SEQUENCE VARIANTS; HUMAN-POPULATIONS; GENETIC-VARIATION; ADULT OBESITY; FTO GENE; RISK | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Partially | ||||
| Item ID: | 62533 |
Abstract
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We ...

Abstract
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 x 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 x 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 x 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 x 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
Metadata last modified: 30 Apr 2025 05:35
Altmetric