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A Novel Mechanism for the Modulation of the Ras-Effector Interaction by small molecules

Kalbitzer, H. R. ; Spoerner, M. ; Graf, T. ; König, B.


When proteins require different conformations for their biological function, all these functional states have to coexist simultaneously in solution. However, the corresponding Gibbs free energy differences are usually rather high and thus the conformation with lowest energy predominates in solution whereas the populations of the states with higher energy (excited states) are very small. A ...


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