Kalbitzer, H. R., Spoerner, M., Graf, T. and König, B. (2005) A Novel Mechanism for the Modulation of the Ras-Effector Interaction by small molecules. Biochem. Biophys. Res. Commun. 334, 709 – 713.
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Abstract
When proteins require different conformations for their biological function, all these functional states have to coexist simultaneously in solution. However, the corresponding Gibbs free energy differences are usually rather high and thus the conformation with lowest energy predominates in solution whereas the populations of the states with higher energy (excited states) are very small. A ...
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| Item type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Date: | 2005 | ||||||
| Institutions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie | ||||||
| Projects: | GRK 760, Graduiertenkolleg Medizinische Chemie | ||||||
| Identification Number: |
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| Keywords: | Ras; 31P NMR; Anti-tumor therapy; Conformational equilibrium | ||||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 6263 |
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