Functionalized N-Aryl-Substituted Cyclens by Nucleophilic Aromatic Substitution

Zusammenfassung

The reaction of trifold protected cyclen with fluorinated dinitroarenes yields aryl-substituted or aryl-bridged cyclen derivatives in good yield. The two arene nitro groups, necessary for the nucleophilic aromatic substitution, are subsequently selectively reduced to amines and further functionalized by amide formation. As an example, a cyclen derivative bearing a heterocyclic oligoamide with potential DNA binding ability was prepared.