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Identification of Der p 23, a Peritrophin-like Protein, as a New Major Dermatophagoides pteronyssinus Allergen Associated with the Peritrophic Matrix of Mite Fecal Pellets

Weghofer, Margit ; Grote, Monika ; Resch, Yvonne ; Casset, Anne ; Kneidinger, Michael ; Kopec, Jolanta ; Thomas, Wayne R. ; Fernández-Caldas, Enrique ; Kabesch, Michael ; Ferrara, Rosetta ; Mari, Adriano ; Purohit, Ashok ; Pauli, Gabrielle ; Horak, Friedrich ; Keller, Walter ; Valent, Peter ; Valenta, Rudolf ; Vrtala, Susanne



Zusammenfassung

The house dust mite (HDM) Dermatophagoides pteronyssinus is one of most important allergen sources and a major elicitor of allergic asthma. We screened a D. pteronyssinus expression cDNA library with IgE Abs from HDM allergic patients. A cDNA coding for a new major allergen was isolated, which showed sequence homology to peritrophins, which contain chitin-binding domains and are part of the ...

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