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Abstract
The synthesis and peptide-binding properties of a Zn(II)nitrilotriacetate complex substituted with pyrimidine hydrazine amides are reported. The metal complex provides millimolar binding affinity in aqueous buffer to peptides bearing N-terminal His. The pyrimidine heterocycles intermolecularly interact with the bound peptide and quench the emission of nearby Trp residues by energy transfer. (c) 2006 Elsevier Ltd. All rights reserved.
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