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Synthesis and Peptide-binding Properties of a Luminescent Pyrimidine Zinc(II) Complex

Li, X. ; Miltschitzky, S. ; Grauer, A. ; Michlová, V. ; König, B.


The synthesis and peptide-binding properties of a Zn(II)nitrilotriacetate complex substituted with pyrimidine hydrazine amides are reported. The metal complex provides millimolar binding affinity in aqueous buffer to peptides bearing N-terminal His. The pyrimidine heterocycles intermolecularly interact with the bound peptide and quench the emission of nearby Trp residues by energy transfer.

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