Abstract
Cα-Tetrasubstituted α-amino acids are widely used to design and prepare peptides and peptide mimics with constrained conformations. Subcategories of these compounds are cyclic Cα-tetrasubstituted α-amino acids, in which both α-substituents are covalently connected. This survey presents recent advances in the synthesis and application of cyclic Cα-tetrasubstituted α-amino acids in a systematic ...
Abstract
Cα-Tetrasubstituted α-amino acids are widely used to design and prepare peptides and peptide mimics with constrained conformations. Subcategories of these compounds are cyclic Cα-tetrasubstituted α-amino acids, in which both α-substituents are covalently connected. This survey presents recent advances in the synthesis and application of cyclic Cα-tetrasubstituted α-amino acids in a systematic order beginning with cyclopropane amino acids, continuing with four, five, six membered rings, and ring structures larger than six-membered. We discuss synthetic routes to the cyclic Cα-tetrasubstituted α-amino acids and their use as conformation determining elements in peptides.
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