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Dicer-dependent and -independent Argonaute2 Protein Interaction Networks in Mammalian Cells

Frohn, Anne ; Eberl, H. Christian ; Stöhr, Julia ; Glasmacher, Elke ; Rüdel, Sabine ; Heissmeyer, Vigo ; Mann, Matthias ; Meister, Gunter



Abstract

Argonaute (Ago) proteins interact with small regulatory RNAs such as microRNAs (miRNAs) and facilitate gene-silencing processes. miRNAs guide Ago proteins to specific mRNAs leading to translational silencing or mRNA decay. In order to understand the mechanistic details of miRNA function, it is important to characterize Ago protein interactors. Although several proteomic studies have been ...

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