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Genetic variants in Protocadherin‐1, bronchial hyper‐responsiveness, and asthma subphenotypes in German children

Toncheva, Antoaneta A. ; Suttner, Kathrin ; Michel, Sven ; Klopp, Norman ; Illig, Thomas ; Balschun, Tobias ; Vogelberg, Christian ; von Berg, Andrea ; Bufe, Albrecht ; Heinzmann, Andrea ; Laub, Otto ; Rietschel, Ernst ; Simma, Burkhard ; Frischer, Thomas ; Genuneit, Jon ; von Mutius, Erika ; Kabesch, Michael



Zusammenfassung

Background: Recently, Protocadherin-1 (PCDH1) was reported as a novel susceptibility gene for bronchial hyper-responsiveness (BHR) and asthma. PCDH1 is located on chromosome 5q31-33, in the vicinity of several known candidate genes for asthma and allergy. To exclude that the associations observed for PCDH1 originate from the nearby cytokine cluster, an extensive linkage disequilibrium (LD) ...

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