The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

Gibson, Greg ; Voight, Benjamin F. ; Kang, Hyun Min ; Ding, Jun ; Palmer, Cameron D.

; Sidore, Carlo ; Chines, Peter S. ; Burtt, Noël P.

; Fuchsberger, Christian ; Li, Yanming

; Erdmann, Jeanette ; Frayling, Timothy M. ; Heid, Iris M. ; Jackson, Anne U.

; Johnson, Toby ; Kilpeläinen, Tuomas O.

; Lindgren, Cecilia M. ; Morris, Andrew P.

; Prokopenko, Inga ; Randall, Joshua C. ; Saxena, Richa

; Soranzo, Nicole ; Speliotes, Elizabeth K. ; Teslovich, Tanya M.

; Wheeler, Eleanor ; Maguire, Jared ; Parkin, Melissa ; Potter, Simon ; Rayner, N. William ; Robertson, Neil ; Stirrups, Kathleen ; Winckler, Wendy ; Sanna, Serena

; Mulas, Antonella ; Nagaraja, Ramaiah ; Cucca, Francesco

; Barroso, Inês

; Deloukas, Panos

; Loos, Ruth J. F. ; Kathiresan, Sekar ; Munroe, Patricia B. ; Newton-Cheh, Christopher ; Pfeufer, Arne ; Samani, Nilesh J. ; Schunkert, Heribert ; Hirschhorn, Joel N.

; Altshuler, David ; McCarthy, Mark I.

; Abecasis, Gonçalo R. ; Boehnke, Michael

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Abstract

Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related traits such as body mass index, glucose and insulin levels, lipid levels, and blood pressure. These studies also have pointed to thousands of loci with promising but not yet compelling association evidence. To establish association at ...