Duvvuri, Umamaheswar ; Shiwarski, Daniel J. 
; Xiao, Dong ; Bertrand, Carol ; Huang, Xin ; Edinger, Robert S. ; Rock, Jason R. ; Harfe, Brian D. ; Henson, Brian J. ; Kunzelmann, Karl ; Schreiber, Rainer ; Seethala, Raja S. ; Egloff, Ann Marie ; Chen, Xing ; Lui, Vivian W. ; Grandis, Jennifer R. ; Gollin, Susanne M.
; Xiao, Dong ; Bertrand, Carol ; Huang, Xin ; Edinger, Robert S. ; Rock, Jason R. ; Harfe, Brian D. ; Henson, Brian J. ; Kunzelmann, Karl ; Schreiber, Rainer ; Seethala, Raja S. ; Egloff, Ann Marie ; Chen, Xing ; Lui, Vivian W. ; Grandis, Jennifer R. ; Gollin, Susanne M. 
Zusammenfassung
Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in human tumorigenesis has not been previously studied. Here, we show a functional role for TMEM16A in tumor growth. We found TMEM16A overexpression in 80% of head and neck squamous cell carcinoma (SCCHN), which ...
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