| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Stress | ||||
| Verlag: | TAYLOR & FRANCIS LTD | ||||
| Ort der Veröffentlichung: | ABINGDON | ||||
| Band: | 15 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 4 | ||||
| Seitenbereich: | S. 403-415 | ||||
| Datum: | 2012 | ||||
| Institutionen: | Medizin > Lehrstuhl für Immunologie Medizin > Lehrstuhl für Innere Medizin I Medizin > Lehrstuhl für Pathologie Biologie und Vorklinische Medizin > Institut für Zoologie Biologie und Vorklinische Medizin > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | DEXTRAN SODIUM-SULFATE; DSS-INDUCED COLITIS; ULCERATIVE-COLITIS; COLORECTAL-CANCER; CELL-PROLIFERATION; TUMOR-METASTASIS; CROHNS-DISEASE; BOWEL-DISEASE; BETA-CATENIN; AZOXYMETHANE; Azoxymethane; chronic psychosocial stress; colitis; colorectal cancer; inflammation; regulatory T cells | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 590 Tiere (Zoologie) 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 63638 |
Web of ScienceZusammenfassung
Patients with inflammatory bowel diseases (IBDs) have a higher risk of developing colorectal cancer (CRC) than the general population. Furthermore, chronic psychosocial stress increases the likelihood of developing IBD and multiple types of malignant neoplasms, including CRC. Here, for the first time, we investigate the effects of chronic psychosocial stress in male mice on an artificially ...
Zusammenfassung
Patients with inflammatory bowel diseases (IBDs) have a higher risk of developing colorectal cancer (CRC) than the general population. Furthermore, chronic psychosocial stress increases the likelihood of developing IBD and multiple types of malignant neoplasms, including CRC. Here, for the first time, we investigate the effects of chronic psychosocial stress in male mice on an artificially induced CRC, by employing the chronic subordinate colony (CSC) housing paradigm in combination with the reliable azoxymethane (AOM)/dextran sodium sulfate (DSS) CRC model. Colonoscopy revealed that CSC mice showed accelerated macroscopic suspect lesions. In addition, more CSC mice developed low-grade dysplasia (LGD) and/or high-grade dysplasia (HGD) in the colonic tissue compared to the single-housed control mice (SHC). CSC mice showed an increased number of Ki67(+) and a decreased number of terminal deoxynucleotidyl transferase dUTP nick end labeling epithelial cells in colonic tissue. Colonic liver receptor homolog-1 (LRH-1), cyclooxygenase II (COXII), tumor necrosis factor, forkhead box P3 (FoxP3) mRNA as well as colonic beta-catenin, COXII, and LRH-1 protein expression were also increased in CSC compared with SHC mice. Although the number of CD4(+) Th cells was increased, a tendency toward a decreased colonic interferon-gamma (IFN-gamma) mRNA expression was observed. Furthermore, despite an increased percentage of CD3(+) cells and CD3(+)/FoxP3(+) double-positive cells within mesenteric lymph node cells of CSC mice, IFN-gamma secretion from these cells was unaffected. Altogether, our results suggest that chronic psychosocial stress increases the risk for AOM/DSS-induced and, thus, inflammation-related CRC. Finally, assessment of additional time points may test whether the shift from tumor-protective Th1 cell to regulatory T-cell immunity represents a consequence of increased carcinogenesis or a causal factor involved in its development.
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