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Journal or Publication Title: | PLoS Genetics | ||||
Publisher: | PUBLIC LIBRARY SCIENCE | ||||
Place of Publication: | SAN FRANCISCO | ||||
Volume: | 8 | ||||
Number of Issue or Book Chapter: | 3 | ||||
Page Range: | e1002584 | ||||
Date: | 2012 | ||||
Institutions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
Identification Number: |
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Keywords: | GLOMERULAR-FILTRATION-RATE; GENE-EXPRESSION; SERUM CREATININE; COLLABORATIVE METAANALYSIS; HIGHER ALBUMINURIA; DISEASE; ZEBRAFISH; ORGANIZATION; BRAIN; GFR; | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 63960 |
Abstract
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, ...

Abstract
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
Metadata last modified: 19 Dec 2024 09:42