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Common Genetic Variation in the 3′- BCL11B Gene Desert Is Associated With Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk

Mitchell, Gary F. ; Verwoert, Germaine C. ; Tarasov, Kirill V. ; Isaacs, Aaron ; Smith, Albert V. ; Yasmin, ; Rietzschel, Ernst R. ; Tanaka, Toshiko ; Liu, Yongmei ; Parsa, Afshin ; Najjar, Samer S. ; O'Shaughnessy, Kevin M. ; Sigurdsson, Sigurdur ; De Buyzere, Marc L. ; Larson, Martin G. ; Sie, Mark P.S. ; Andrews, Jeanette S. ; Post, Wendy S. ; Mattace-Raso, Francesco U.S. ; McEniery, Carmel M. ; Eiriksdottir, Gudny ; Segers, Patrick ; Vasan, Ramachandran S. ; van Rijn, Marie Josee E. ; Howard, Timothy D. ; McArdle, Patrick F. ; Dehghan, Abbas ; Jewell, Elizabeth S. ; Newhouse, Stephen J. ; Bekaert, Sofie ; Hamburg, Naomi M. ; Newman, Anne B. ; Hofman, Albert ; Scuteri, Angelo ; De Bacquer, Dirk ; Arfan Ikram, Mohammad ; Psaty, Bruce M. ; Fuchsberger, Christian ; Olden, Matthias ; Wain, Louise V. ; Elliott, Paul ; Smith, Nicholas L. ; Felix, Janine F. ; Erdmann, Jeanette ; Vita, Joseph A. ; Sutton-Tyrrell, Kim ; Sijbrands, Eric J.G. ; Sanna, Serena ; Launer, Lenore J. ; De Meyer, Tim ; Johnson, Andrew D. ; Schut, Anna F.C. ; Herrington, David M. ; Rivadeneira, Fernando ; Uda, Manuela ; Wilkinson, Ian B. ; Aspelund, Thor ; Gillebert, Thierry C. ; Van Bortel, Luc ; Benjamin, Emelia J. ; Oostra, Ben A. ; Ding, Jingzhong ; Gibson, Quince ; Uitterlinden, André G. ; Abecasis, Gonçalo R. ; Cockcroft, John R. ; Gudnason, Vilmundur ; De Backer, Guy G. ; Ferrucci, Luigi ; Harris, Tamara B. ; Shuldiner, Alan R. ; van Duijn, Cornelia M. ; Levy, Daniel ; Lakatta, Edward G. ; Witteman, Jacqueline C.M.



Zusammenfassung

Background-Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events. Methods and Results-We conducted a meta-analysis of genome-wide association data in 9 community-based European ancestry cohorts consisting of 20 634 participants. Results were replicated in 2 additional European ...

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