| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Neuropharmacology | ||||
| Verlag: | PERGAMON-ELSEVIER SCIENCE LTD | ||||
| Ort der Veröffentlichung: | OXFORD | ||||
| Band: | 62 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 | ||||
| Seitenbereich: | S. 398-405 | ||||
| Datum: | 2012 | ||||
| Institutionen: | Biologie und Vorklinische Medizin > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | BLOOD-BRAIN-BARRIER; ELEVATED PLUS-MAZE; SPATIAL MEMORY; PARAVENTRICULAR NUCLEUS; OBJECT RECOGNITION; OXYTOCIN; VASOPRESSIN; RECEPTOR; SYSTEM; HUMANS; Neuropeptide S; Memory; Plus-maze; Nasal; Anxiety; Rats | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 590 Tiere (Zoologie) | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 64292 |
Web of ScienceZusammenfassung
Recent studies demonstrated potent behavioral effects of centrally applied neuropeptide S (NPS) in mice and rats. These include increased arousal and wakefulness, facilitation of fear extinction and object memory consolidation and anxiolysis. Here, we compared the effects of NPS on both social and non-social memory, in male rats, and on social preference/social anxiety versus non-social anxiety ...
Zusammenfassung
Recent studies demonstrated potent behavioral effects of centrally applied neuropeptide S (NPS) in mice and rats. These include increased arousal and wakefulness, facilitation of fear extinction and object memory consolidation and anxiolysis. Here, we compared the effects of NPS on both social and non-social memory, in male rats, and on social preference/social anxiety versus non-social anxiety after either intracerebroventricular (icy) or nasal application. Intranasal application of neuropeptides has been successfully employed to alter behavioral parameters in humans and rodents, but studies concerning nasal application of NPS are lacking so far. First, we confirmed the facilitatory effect of icy NPS (1 nmol) on object discrimination after an inter-exposure interval (IEI) of 240 min. These effects were context-dependent, as icy NPS (1 nmol) did not prolong social memory in a social discrimination paradigm. Second, we confirmed the anxiolytic effect of icy NPS (1 nmol) on the elevated plus-maze, whereas neither icy NPS (1 nmol) nor NPS receptor antagonist (10 nmol) altered social preference/social avoidance behavior. Third, nasal NPS (4-40 nmol applied topically on the rhinarium) facilitated object discrimination in a dose-dependent manner. Also, the anxiolytic effect of NPS on the elevated plus-maze could be confirmed after nasal administration (40 nmol). In contrast, identical doses of subcutaneously injected NPS failed to produce corresponding behavioral effects in both tests. Our findings provide evidence for memory-enhancing and anxiolytic effects of icy NPS in a non-social context. We could further show that these effects are context-specific, as social memory and social preference behavior remained unchanged after icy NPS. The effects of icy NPS were replicated by nasal application of the neuropeptide. Thus, nasal application of NPS seems to be a useful method in rodents for screening for behavioral or physiological effects before more specific and time-consuming, intracerebral methods are employed, and may represent a viable therapeutic approach for NPS treatment of patients with psychiatric illnesses such as anxiety or panic disorders. This article is part of a Special Issue entitled 'Anxiety and Depression'. (C) 2011 Elsevier Ltd. All rights reserved.
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