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Targeted Luminescent Near-Infrared Polymer-Nanoprobes for In Vivo Imaging of Tumor Hypoxia

Napp, Joanna ; Behnke, Thomas ; Fischer, Lorenz ; Würth, Christian ; Wottawa, Marieke ; Katschinski, Dörthe M. ; Alves, Frauke ; Resch-Genger, Ute ; Schäferling, Michael



Zusammenfassung

Polystyrene nanoparticles (PS-NPs) were doped with an oxygen-sensitive near-infrared (NIR)-emissive palladium meso-tetraphenylporphyrin and an inert reference dye which are both excitable at 635 nm. The nanosensors were characterized with special emphasis on fundamental parameters such as absolute photoluminescence quantum yield and fluorescence lifetime. The PS-NPs were employed for ratiometric ...

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