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Improved NYVAC-Based Vaccine Vectors

Lesniak, Maciej S. ; Kibler, Karen V. ; Gomez, Carmen E. ; Perdiguero, Beatriz ; Wong, Shukmei ; Huynh, Trung ; Holechek, Susan ; Arndt, William ; Jimenez, Victoria ; Gonzalez-Sanz, Ruben ; Denzler, Karen ; Haddad, Elias K. ; Wagner, Ralf ; Sékaly, Rafick P. ; Tartaglia, James ; Pantaleo, Giuseppe ; Jacobs, Bertram L. ; Esteban, Mariano



Zusammenfassung

While as yet there is no vaccine against HIV/AIDS, the results of the phase III Thai trial (RV144) have been encouraging and suggest that further improvements of the prime/boost vaccine combination of a poxvirus and protein are needed. With this aim, in this investigation we have generated derivatives of the candidate vaccinia virus vaccine vector NYVAC with potentially improved functions. This ...

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