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Phenotype Severity in the Bladder Exstrophy-Epispadias Complex: Analysis of Genetic and Nongenetic Contributing Factors in 441 Families from North America and Europe

Reutter, Heiko ; Boyadjiev, Simeon A. ; Gambhir, Lisa ; Ebert, Anne-Karoline ; Rösch, Wolfgang H. ; Stein, Raimund ; Schröder, Annette ; Boemers, Thomas M. ; Bartels, Enrika ; Vogt, Hannes ; Utsch, Boris ; Müller, Martin ; Detlefsen, Birte ; Zwink, Nadine ; Rogenhofer, Sebastian ; Gobet, Rita ; Beckers, Goedele M.A. ; Bökenkamp, Arend ; Kajbafzadeh, Abdol-Mohammad ; Jaureguizar, Enrique ; Draaken, Markus ; Lakshmanan, Yegappan ; Gearhart, John P. ; Ludwig, Michael ; Nöthen, Markus M. ; Jenetzky, Ekkehart



Zusammenfassung

Objective To identify genetic and nongenetic risk factors that contribute to the severity of the bladder exstrophy-epispadias complex (BEEC). Study design Patients with BEEC from North America (n = 167) and Europe (n = 274) were included. The following data were collected: associated anomalies, parental age at conception, mode of conception, periconceptional folic acid supplementation, maternal ...

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