Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials

Maringwa, John T. ; Quinten, Chantal ; King, Madeleine ; Ringash, Jolie

; Osoba, David ; Coens, Corneel ; Martinelli, Francesca ; Vercauteren, Jurgen ; Cleeland, Charles S. ; Flechtner, Henning ; Gotay, Carolyn ; Greimel, Eva ; Taphoorn, Martin J. ; Reeve, Bryce B. ; Koch, Joseph Schmucker-Von ; Weis, Joachim ; Smit, Egbert F. ; van Meerbeeck, Jan P. ; Bottomley, Andrew

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Abstract

The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). WHO performance status (PS) and weight change ...