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Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD

Kim, Stuart K. ; Böger, Carsten A. ; Gorski, Mathias ; Li, Man ; Hoffmann, Michael M. ; Huang, Chunmei ; Yang, Qiong ; Teumer, Alexander ; Krane, Vera ; O'Seaghdha, Conall M. ; Kutalik, Zoltán ; Wichmann, H.-Erich ; Haak, Thomas ; Boes, Eva ; Coassin, Stefan ; Coresh, Josef ; Kollerits, Barbara ; Haun, Margot ; Paulweber, Bernhard ; Köttgen, Anna ; Li, Guo ; Shlipak, Michael G. ; Powe, Neil ; Hwang, Shih-Jen ; Dehghan, Abbas ; Rivadeneira, Fernando ; Uitterlinden, André ; Hofman, Albert ; Beckmann, Jacques S. ; Krämer, Bernhard K. ; Witteman, Jacqueline ; Bochud, Murielle ; Siscovick, David ; Rettig, Rainer ; Kronenberg, Florian ; Wanner, Christoph ; Thadhani, Ravi I. ; Heid, Iris M. ; Fox, Caroline S. ; Kao, W. H.



Abstract

Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 ...

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