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Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

Hutchinson, James A. ; Riquelme, Paloma ; Sawitzki, Birgit ; Tomiuk, Stefan ; Miqueu, Patrick ; Zuhayra, Maaz ; Oberg, Hans H. ; Pascher, Andreas ; Lützen, Ulf ; Janßen, Uwe ; Broichhausen, Christiane ; Renders, Lutz ; Thaiss, Friedrich ; Scheuermann, Ernst ; Henze, Eberhard ; Volk, Hans-Dieter ; Chatenoud, Lucienne ; Lechler, Robert I. ; Wood, Kathryn J. ; Kabelitz, Dieter ; Schlitt, Hans J. ; Geissler, Edward K. ; Fändrich, Fred



Zusammenfassung

Regulatory macrophages (M regs) were administered to two living-donor renal transplant recipients. Both patients were minimized to low-dose tacrolimus monotherapy within 24 wk of transplantation and subsequently maintained excellent graft function. After central venous administration, most M regs remained viable and were seen to traffic from the pulmonary vasculature via the blood to liver, ...

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