Melnik, Bodo C ; John, Swen ; Schmitz, Gerd 
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Nutrition & Metabolism |
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| Verlag: | BMC |
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| Ort der Veröffentlichung: | LONDON |
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| Band: | 8 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 |
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| Seitenbereich: | S. 41 |
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| Datum: | 2011 |
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| Institutionen: | Medizin > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1186/1743-7075-8-41 | DOI |
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| Stichwörter / Keywords: | FOXO TRANSCRIPTION FACTORS; FORKHEAD PROTEIN FOXO1; ACNE-VULGARIS; CANCER; GROWTH; MILK; LIFE; PATHWAY; MUTANT; RISK; |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 64841 |
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Web of Science
Zusammenfassung
The insulin/insulin-like growth factor-1 (IGF-1) pathway drives an evolutionarily conserved network that regulates lifespan and longevity. Individuals with Laron syndrome who carry mutations in the growth hormone receptor (GHR) gene that lead to severe congenital IGF-1 deficiency with decreased insulin/ IGF-1 signaling (IIS) exhibit reduced prevalence rates of acne, diabetes and cancer. Western ...
Zusammenfassung
The insulin/insulin-like growth factor-1 (IGF-1) pathway drives an evolutionarily conserved network that regulates lifespan and longevity. Individuals with Laron syndrome who carry mutations in the growth hormone receptor (GHR) gene that lead to severe congenital IGF-1 deficiency with decreased insulin/ IGF-1 signaling (IIS) exhibit reduced prevalence rates of acne, diabetes and cancer. Western diet with high intake of hyperglycemic carbohydrates and insulinotropic dairy over-stimulates IIS. The reduction of IIS in Laron subjects unmasks the potential role of persistent hyperactive IIS mediated by Western diet in the development of diseases of civilization and offers a rational perspective for dietary adjustments with less insulinotropic diets like the Paleolithic diet.
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